… , cisplatin-DNA binding levels in liver and brain mitochondrial … lack of nucleotide excision
repair pathways in mitochondria, … decreases platinum–mtDNA adducts to protect renal tubular …

… both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) … Studies in Chinese hamster
ovary cells showed that cisplatin … indicates that formation of a cisplatin-DNA adduct (intra- or …

… of cisplatin–DNA adducts and their poor removal were reported for mitochondrial DNA as
compared to nuclear DNA … In this work, PrimPol preferentially incorporated two complementary …

… not due to preferential repair of transplatin lesions by nucleotide … for forming mitochondrial
DNA (mtDNA) adducts than nDNA … Furthermore, in Chinese hamster ovary cells, there is not …

… Cisplatin–DNA adducts were quantified using the rat mAb CP9… E, Mitochondrial DNA content
normalized by nuclear DNA … ovarian cancer cell, preferentially cisplatin-resistant cells. Our …

… due to larger N7 guanine content of the mitochondrial DNA. … Cisplatin based combination
chemotherapy is preferred in … further reduction of cisplatin-DNA adducts formation. Reduction in …

… Citation10 The most common cisplatin-DNA adduct formation … The preference of cisplatin’s
affinity towards guanine at the N7… Cisplatin binds to mitochondrial DNA as well leading to cell …

… Platinum atoms bind preferentially to the nitrogen atom at … TATA box and the cisplatin-DNA
adduct. Consequently, this … toxin and damages nuclear and mitochondrial DNA, causing ROS …

… , mtDNA loss or a decrease in the number of functional copies of the mitochondrial genome
… of POLβ versus POLγ in gap filling correlates with preference for either short-patch or long-…

… translesion DNA synthesis, and an increase in nucleotide excision … Less prominent is the fact
that mitochondrial DNA (mtDNA) … mtDNA adducts possibly interferes with the transcription of …